Significant changes in yields of 7-hydroxy-coumarin-3-carboxylic acid produced under FLASH radiotherapy conditions
Tamon Kusumoto, Hisashi Kitamura, Satoru Hojo, Teruaki Konishi, Satoshi Kodaira
Abstract
values of 7OH-C3CA produced reduce with increasing dose rate due to the oxygen depletion. We experimentally present that the sparing effect for healthy tissues would be seen even with a proton beam under the FLASH conditions due to the depletion of oxygen.
Topics & Concepts
RadicalRadiolysisChemistryIrradiationCarboxylic acidCoumarinPhotochemistryHydroxyl radicalProtonScavengingOxygenScavengerReaction rate constantRadiochemistryFlash (photography)Nuclear chemistryAntioxidantOrganic chemistryKineticsPhysicsArtQuantum mechanicsNuclear physicsVisual artsRadiation Therapy and DosimetryAdvanced Radiotherapy TechniquesRadiation Effects and Dosimetry