Design and linkage optimization of ursane-thalidomide-based PROTACs and identification of their targeted-degradation properties to MDM2 protein
Zhiwen Qi, Yang Gu-liang, Tao Deng, Jianmin Wang, Hao Zhou, Sergey A. Popov, Elvira E. Shults, Chengzhang Wang
Topics & Concepts
ChemistryTarget proteinLigand (biochemistry)Protein degradationLead compoundA549 cellProteolysisMdm2BiochemistryStereochemistryIn vitroApoptosisReceptorEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments