The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma
Alexander Ou, Martina Ott, Dexing Fang, Amy B. Heimberger
Abstract
Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.
Topics & Concepts
statJanus kinaseSTAT proteinJAK-STAT signaling pathwayCancer researchSignal transductionAngiogenesisJanus kinase 2GlioblastomaSTAT3Immune systemBiologyMedicineImmunologyCell biologyTyrosine kinaseCytokine Signaling Pathways and InteractionsCancer Mechanisms and TherapyFOXO transcription factor regulation