Hypouricemic, hepatoprotective and nephroprotective roles of oligopeptides derived from<i>Auxis thazard</i>protein in hyperuricemic mice
Liuyi Wei, Hongwu Ji, Wenkui Song, Shuo Peng, Suhong Zhan, Yushan Qu, Ming Chen, Di Zhang, Shucheng Liu
Abstract
< 0.05), and accelerated UA excretion by downregulating the gene expression of renal mURAT1 and mGLUT9 and upregulating the gene expression of mABCG2 and mOAT1. ATO could also reduce the levels of liver MDA, increase the activities of SOD and CAT, and reduce the levels of IL-1β, MCP-1 and TNF-α. Histological analysis also showed that ATO possessed hepatoprotective and nephroprotective activities in hyperuricemic mice. Thus, ATO could reduce the serum UA level in hyperuricemic mice by decreasing UA production and promoting UA excretion from the kidney, suggesting that ATO could be developed as a dietary supplement for hyperuricemia treatment.