All-optical interrogation of brain-wide activity in freely swimming larval zebrafish
Yuming Chai, Kexin Qi, Yubin Wu, Daguang Li, Guodong Tan, Yuqi Guo, Jun Chu, Mu Yu, C.-K. James Shen, Quan Wen
Abstract
selective optogenetic stimulation of different regions of the brain. By demonstrating that selective light activation of the midbrain regions in larval zebrafish could reliably trigger biased turning behavior and changes of brain-wide neural activity, we present a valuable tool for investigating the causal relationship between distributed neural circuit dynamics and naturalistic behavior.
Topics & Concepts
OptogeneticsCalcium imagingZebrafishNeuroscienceBrain activity and meditationFluorescent proteinMidbrainNeural activityPremovement neuronal activitySystems neurosciencePhotic StimulationComputer scienceBiologyChemistryGreen fluorescent proteinCalciumElectroencephalographyVisual perceptionCentral nervous systemGenePerceptionOrganic chemistryBiochemistryMyelinOligodendrocyteZebrafish Biomedical Research ApplicationsPhotoreceptor and optogenetics researchRetinal Development and Disorders