Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization
David F. Fernández, María González‐Esguevillas, Sebastian Keeß, Felix Schäfer, Jens Mohr, Andre Shavnya, Thomas Knauber, David C. Blakemore, David W. C. MacMillan
Abstract
C(sp 3 )-rich aliphatic motifs in drug molecules are strongly associated with clinical success. Historically, the availability of compound libraries based on C(sp 3 )-rich cores has been limited due to the challenging direct functionalization of aliphatic rings. Instead, most small molecule drug-like libraries are diversified around central aromatic rings. Herein, we present a general approach to the synthesis of diversified libraries featuring aliphatic core rings via photoredox catalysis under mild conditions.
Topics & Concepts
ChemistrySurface modificationPhotoredox catalysisCore (optical fiber)Combinatorial chemistryCatalysisOrganic chemistryPhotocatalysisComputer scienceTelecommunicationsPhysical chemistryRadical Photochemical ReactionsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques