Targeting MCOLN1/TRPML1 channels to protect against ischemia-reperfusion injury by restoring the inhibited autophagic flux in cardiomyocytes
Zhongheng Sui, Mengmeng Wang, Yanhong Xing, Jiansong Qi, Wuyang Wang
Abstract
I/R: ischemia-reperfusion; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCOLN1/TRPML1: mucolipin TRP cation channel 1; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1.
Topics & Concepts
AutophagyCell biologyBiologyReactive oxygen speciesReperfusion injuryMitochondrionCardioprotectionFlux (metallurgy)IschemiaApoptosisBiochemistryChemistryInternal medicineMedicineOrganic chemistryAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismMitochondrial Function and Pathology