Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity
Verrill M. Norwood, Ariana C. Brice‐Tutt, Shainnel O. Eans, Heather M. Stacy, Guqin Shi, Ranjala Ratnayake, James R. Rocca, Khalil A. Abboud, Chenglong Li, Hendrik Luesch, Jay P. McLaughlin, Robert W. Huigens
Abstract
) significantly prevented acute morphine-conditioned place preference (CPP) and stress-induced reinstatement of extinguished morphine-CPP in mouse models of opioid reward and relapse. These results demonstrate that the ring distortion of vincamine offers a promising way to explore new chemical space of relevance to opioid addiction.
Topics & Concepts
ChemistryMorphineOrexinPharmacologyOpioidG protein-coupled receptorConditioned place preferenceAddictionOpioid receptorReceptorNeurosciencePsychologyNeuropeptideMedicineBiochemistryAlkaloids: synthesis and pharmacologyNeuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling