Identification of Two Variants of Acinetobacter baumannii Strain ATCC 17978 with Distinct Genotypes and Phenotypes
Christiaan D. M. Wijers, Ly Pham, Swapna Menon, Kelli L. Boyd, Hannah R. Noel, Eric P. Skaar, Jennifer A. Gaddy, Lauren D. Palmer, Michael J. Noto
Abstract
. The accessory cardiolipin synthase plays a dichotomous role by promoting bacterial uptake and increasing IL-1β production by macrophages, but also by enhancing bacterial resistance to cell envelope stress. Collectively, these findings highlight the phenotypic consequences of the genomic dynamism of A. baumannii through the evolution of two variants of a common type strain with distinct infection-related attributes.
Topics & Concepts
BiologyAcinetobacter baumanniiMicrobiologyPhenotypeGeneticsGenotypePilusGenePathogenBacterial geneticsVirulenceLocus (genetics)NeisseriaceaeAntibiotic resistanceBacteriagenomic DNAMultilocus sequence typingStrain (injury)Fimbriae ProteinsIntergenic regionSigma factorPathogenesisTypingAntibiotic Resistance in BacteriaGenomics and Phylogenetic StudiesBerberine and alkaloids research