Organ-on-a-chip: key industry insights, challenges, and opportunities from 100+ NSF I-Corps interviews
Ronin-Mae Komarnisky, Shaun Wootten, Nathan Friedman, Mehdi Nikkhah
Abstract
102) interviews with OoC experts, clinicians, and professionals across the pharmaceutical and biotech industries. This perspective article summarizes our collective effort and the insights gained from this program, offering valuable knowledge for the OoC community. Overall, the vision of our NSF I-Corps interviewees highlighted the urgent need for OoC standardization, reproducibility, reliability, scalability, as well as ease of usability along with regulatory acceptance. Moreover, these interviews highlighted a critical gap between academic innovations and commercial applications, emphasizing the importance of bridging collaboration between the two entities. This perspective further explores the current commercialization potential of OoC technologies and outlines the key hurdles that must be addressed for OoC technologies to achieve broader adoption in drug discovery and personalized medicine.