Inactivation of <i>Exosc10</i> in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice
Leïla Demini, Christine Kervarrec, Laëtitia Guillot, Emmanuelle Com, Régis Lavigne, Pierre-Yves Kernanec, Michael Primig, Charles Pineau, Fabrice G. Petit, Soazik P. Jamin
Abstract
knockout mouse ovaries, and identified EXOSC10-dependent proteins involved in many biological processes, such as meiotic cell cycle progression and oocyte maturation. Our results unambiguously demonstrate an essential role for EXOSC10 in oogenesis and may serve as a model for primary ovarian insufficiency in humans. Data are available via ProteomeXchange with identifier PXD039417.
Topics & Concepts
OocyteBiologyOogenesisCell biologyOvarian follicleAndrologyEmbryoInternal medicineEndocrinologyOvaryMedicineReproductive Biology and FertilityRNA Research and SplicingReproductive System and Pregnancy