Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies
Rabia Mehmood, Amina Sadiq, Reem I. Alsantali, Ehsan Ullah Mughal, Meshari A. Alsharif, Nafeesa Naeem, Asif Javid, Munirah M. Al‐Rooqi, Gul-e-Saba Chaudhry, Saleh A. Ahmed
Abstract
showed moderate cytotoxic activity against MCF-7 and HeLa cell lines. Moreover, in silico studies on most active compounds were also performed to understand the binding interaction of most active compounds with active sites of urease and α-glucosidase enzymes. Some compounds exhibited drug-like characteristics due to their lower cytotoxic and good ADME profiles.
Topics & Concepts
ChemistryCombinatorial chemistryDual (grammatical number)Cytotoxic T cellDrugPyrazolinePharmacologyStereochemistryBiochemistryMedicineIn vitroOrganic chemistryPhilosophyLinguisticsSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsMicrobial Applications in Construction Materials