Encoding BRAF inhibitor functions in protein degraders
Daniel S. J. Miller, Sabine Anna Voell, Izidor Sosič, Matic Proj, Olivia W. Rossanese, Gregor Schnakenburg, Michael Gütschow, Ian Collins, Christian Steinebach
Abstract
Novel BRAF V600E PROTACs were developed that maintain target degradation while sparing paradoxical activation of the MAPK pathway in BRAF wt cells.
Topics & Concepts
Cancer researchMAPK/ERK pathwayDegradation (telecommunications)V600EComputational biologyMutationBiologyChemistryCell biologyComputer scienceSignal transductionGeneticsGeneTelecommunicationsProtein Degradation and InhibitorsMelanoma and MAPK PathwaysUbiquitin and proteasome pathways