On-demand biomanufacturing through synthetic biology approach
Chenwang Tang, Lin Wang, Lei Zang, Qing Wang, Dianpeng Qi, Zhuojun Dai
Abstract
Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and monoclonal antibodies, are currently the mainstay products of the biotechnology industry. However, the need for specialized equipment and refrigeration during production and distribution poses challenges for the delivery of these technologies to the field and low-resource area. With the development of synthetic biology, multiple studies rewire the cell-free system or living cells to impact the portable, on-site and on-demand manufacturing of biomolecules. Here, we review these efforts and suggest future directions.
Topics & Concepts
BiomanufacturingSynthetic biologyComputational biologyNanotechnologyComputer scienceBiochemical engineeringBiotechnologyBiologyEngineeringMaterials scienceCRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in InsectsMonoclonal and Polyclonal Antibodies Research