Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression
Tracy Liu, Seth T. Gammon, Ping Yang, David Fuentes, David Piwnica‐Worms
Abstract
cytotoxic T cells, and decreased tumor growth. Overall, these data reveal a role for MDC-derived HOCl as a small-molecule paracrine signaling factor that trans-inhibits IKK in melanoma tumor cells, mediating antitumor responses during early tumor progression.
Topics & Concepts
Paracrine signallingCancer researchEffectorMyeloid cellsMelanomaTumor microenvironmentCell growthChemistryMyeloidNF-κBCell biologyBiologyTumor cellsImmunologySignal transductionReceptorBiochemistryImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and Inflammation