Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial
Dalane W. Kitzman, James B. Young, Michael W. Rich, Kirkwood F. Adams, Michael R. Zile, Wilbert S. Aronow, Jerome L. Fleg, Thomas E. Love, Ali Ahmed, Mihai Gheorghiade
Abstract
About half of the 5 million heart failure patients in the United States have diastolic heart failure (clinical heart failure with normal or near normal ejection fraction). Except for candesartan, no drugs have been tested in randomized clinical trials in these patients. Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study has not been previously published.
Topics & Concepts
DigitalisDigoxinHeart failureMedicineInternal medicineCardiologyDiastolic heart failureDiastoleBlood pressureEjection fractionCardiovascular Function and Risk Factors