Successful transfer of anti–SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19
Tim Luetkens, Ryan A. Metcalf, Vicente Planelles, Yue Zheng, Erin T. Larragoite, Emily S Spivak, Adam M. Spivak, Mary Steinbach, Robert C. Blaylock, Stephanie V. Avila, Kim G. Hankey, Thomas B. Martins, Patricia Slev, Heather D. Mannuel, Mohammad M. Sajadi, Aaron P. Rapoport, Djordje Atanackovic
Abstract
Key Points A severely immunocompromised patient with MM and COVID19 who received a convalescent plasma product showed SARS-CoV-2 clearance. The convalescent plasma showed humoral immunity against all structural SARS-CoV-2 proteins, which was successfully transferred to the patient.
Topics & Concepts
Convalescent plasmaHypogammaglobulinemiaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineImmunityVirologyHumoral immunity2019-20 coronavirus outbreakImmunologyCellular immunityCoronavirusConvalescenceAntibodyImmune systemInternal medicineOutbreakDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchImmunodeficiency and Autoimmune DisordersCOVID-19 Clinical Research Studies