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Gamma-Secretase Inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway

Zimei Dong, Jinrui Huo, Ang Liang, Jinzi Chen, Guangwen Chen, Dezeng Liu

2021The Science of The Total Environment60 citationsDOI

Topics & Concepts

PlanarianNotch signaling pathwayRegeneration (biology)ApoptosisCell biologyNeurotoxicitySignal transductionDrugCell fate determinationCell growthPharmacologyCancer researchBiologyMedicineInternal medicineGeneToxicityBiochemistryTranscription factorPlanarian Biology and ElectrostimulationMarine Ecology and Invasive Speciesbioluminescence and chemiluminescence research
Gamma-Secretase Inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway | Litcius