Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits
Joshua M. Wang, Andrew L. Woodruff, Matthew J. Dunn, Robert J. Fillinger, Richard J. Bennett, Matthew Z. Anderson
Abstract
isolates. Analysis of this transcriptional data set uncovered clear trends in gene expression characteristics for this species and new genes and pathways that were associated with variation in pathogenic processes. Direct investigation confirmed functional predictions for a number of new regulators associated with growth and filamentation, demonstrating the utility of these approaches in linking genes to important phenotypes.
Topics & Concepts
BiologyPhenotypeCandida albicansGenotypeGeneticsComputational biologyGeneAntifungal resistance and susceptibilityFungal Infections and StudiesPlant Pathogens and Fungal Diseases