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Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice

Ting Zheng, Yanping Gu, Jiangmeng Wang, Tingting Huang, Lingshan Gou, Yao‐Wu Liu

2025Chemico-Biological Interactions25 citationsDOI

Topics & Concepts

NephrinPodocyteDiabetic nephropathyEndocrinologyInternal medicineLactate dehydrogenaseBiologyEpithelial–mesenchymal transitionKidneyHistone H3HistoneChemistryDownregulation and upregulationBiochemistryMedicineGeneEnzymeProteinuriaChronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesGenetic and Kidney Cyst Diseases
Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice | Litcius