Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation
Luca Broggini, Maria Monica Barzago, Valentina Speranzini, Schulte Tim, Federica Sonzini, Matteo Giono, Margherita Romeo, Paolo Milani, Serena Caminito, Giulia Mazzini, Paola Rognoni, Giampaolo Merlini, Carlo Pappone, Luigi Anastasia, Mario Nuvolone, Giovanni Palladini, Luisa Diomede, Stéfano Ricagno
Topics & Concepts
ToxicityImmunoglobulin light chainChemistryContext (archaeology)CardiotoxicityAmyloidosisAmyloid (mycology)AL amyloidosisIn vivoFunction (biology)BiochemistryPeptidePharmacologyComputational biologyAntibodyCell biologyBiologyMedicineImmunologyPathologyBiotechnologyInorganic chemistryOrganic chemistryPaleontologyMonoclonal and Polyclonal Antibodies ResearchAmyloidosis: Diagnosis, Treatment, OutcomesGalectins and Cancer Biology