Tracking Ca <sup>2+</sup> ATPase intermediates in real time by x-ray solution scattering
H. Ravishankar, Martin Nors Pedersen, Mattias Eklund, Aljona Sitsel, Chenge Li, Annette Duelli, Matteo Levantino, Michaël Wulff, Andreas Barth, Claus Olesen, Poul Nissen, Magnus Andersson
Abstract
and ATP. A subsequent 13-ms transient state showed a previously unresolved actuator (A) domain arrangement that exposed the ADP-binding site after phosphorylation. Hence, the obtained TR-XSS models determine the relative timing of so-far elusive domain rearrangements in a native environment.
Topics & Concepts
Tracking (education)ScatteringPhysicsATPaseChemistryBiophysicsCrystallographyEnzymeOpticsNuclear magnetic resonanceBiologyPedagogyPsychologyEnzyme Structure and FunctionProtein Structure and DynamicsATP Synthase and ATPases Research