Enhancing glycan stability <i>via</i> site-selective fluorination: modulating substrate orientation by molecular design
Alexander Axer, Ravindra P. Jumde, Sebastian Adam, Andreas Faust, Michael Schäfers, Manfred Fobker, Jesko Koehnke, Anna K. H. Hirsch, Ryan Gilmour
Abstract
)-F bioisosteres in medicinal chemistry, and the importance of maltodextrins in bacterial imaging, this discovery begins to reconcile the information-rich nature of carbohydrates with their intrinsic hydrolytic vulnerabilities.
Topics & Concepts
ChemistryActive siteMaltoseHydrolysisAmylaseGlycoside hydrolaseStereochemistryHydrolaseGlycanSubstrate (aquarium)Combinatorial chemistryMonosaccharideEnzymeBiochemistryGlycoproteinGeologyOceanographyAmino Acid Enzymes and MetabolismCarbohydrate Chemistry and SynthesisFolate and B Vitamins Research