Cryptoyunnanones A–H, Complex Flavanones from <i>Cryptocarya yunnanensis</i>
Qian He, Yue Fan, Yu Liu, Li Rao, Yun‐Xia You, Yu Su, Zhen Zhou, You‐Kai Xu, Chuan‐Rui Zhang
Abstract
Eight new complex flavanones with a novel linkage, cryptoyunnanones A–H (1–8), together with four known α-pyrones, were isolated from the leaves and twigs of Cryptocarya yunnanensis. The structures of 1–8 including their absolute configurations were characterized by spectroscopic data analysis and single-crystal X-ray crystallography. Plausible biosynthetic pathways for the formation of compounds 1–8 were proposed. Compounds 1–4 exhibited cytotoxicity against HCT-116, MDA-MB-231, and PC-3 cancer cells with IC50 values from 6.4 to 9.1 μM.
Topics & Concepts
StereochemistryCytotoxicityChemistryAbsolute configurationIn vitroBiochemistryTraditional and Medicinal Uses of AnnonaceaeNatural product bioactivities and synthesisPlant biochemistry and biosynthesis