An ultra-fast UPLC-MS/MS approach for the quantification of baricitinib in the HLM matrix: greenness assessment with application to <i>in vitro</i> and <i>in silico</i> metabolic stability studies
Mohamed W. Attwa, Ali S. Abdelhameed, Adnan A. Kadi
Abstract
Metabolic stability studies demonstrated moderate baricitinib extraction ratio. Minor adjustments to the pyrrole (88%) and pyrimidine (5%), during drug design, may increase novel derivatives' safety and metabolic stability compared to baricitinib.
Topics & Concepts
In silicoChemistryIn vitroMatrix (chemical analysis)Metabolic stabilityChromatographyBiochemistryGeneAnalytical Methods in PharmaceuticalsAntibiotics Pharmacokinetics and EfficacyAnalytical Chemistry and Chromatography