Zika virus spreads through infection of lymph node-resident macrophages
Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael Diamond, Theodore C. Pierson, Heather D. Hickman
Abstract
macrophages alone is sufficient to initiate viremia. Overall, our experiments indicate that macrophages that reside in the LNs contribute to initial ZIKV spread. These studies enhance our understanding of ZIKV dissemination and identify another anatomical site for potential antiviral intervention.
Topics & Concepts
Zika virusVirologyVirusLymph nodeBiologyImmunologyMedicineMosquito-borne diseases and controlViral Infections and VectorsVirology and Viral Diseases