Litcius/Paper detail

Unified and green oxidation of amides and aldehydes for the Hofmann and Curtius rearrangements

Liyan Song, Yufei Meng, Tongchao Zhao, Lifang Liu, Xiaohong Pan, Binbin Huang, Hongliang Yao, Ran Lin, Rongbiao Tong

2023Green Chemistry21 citationsDOI

Abstract

The oxone–halide green oxidation system is extended to the oxidation of primary amides and aromatic aldehydes (with sodium azide) to generate N -haloamide and acyl azides, respectively, for subsequent Hofmann and Curtius rearrangements.

Topics & Concepts

Curtius rearrangementSodium azideChemistryHalideAzideOrganic chemistrySodiumChemical Synthesis and ReactionsOxidative Organic Chemistry ReactionsChemical Synthesis and Analysis