Assessment of MR Imaging and CT in Differentiating Hereditary and Nonhereditary Paragangliomas
Yoshiaki Ota, Shotaro Naganawa, Ryo Kurokawa, Jayapalli Rajiv Bapuraj, Arístides A. Capizzano, John Kim, Toshio Moritani, Ashok Srinivasan
Abstract
BACKGROUND AND PURPOSE: Head and neck paragangliomas have been reported to be associated with mutations of the succinate dehydrogenase enzyme family. The aim of this study was to assess whether radiologic features could differentiate between paragangliomas in the head and neck positive and negative for the succinate dehydrogenase mutation. MATERIALS AND METHODS: < .05 was considered significant. RESULTS: , and tumor characteristics were not statistically significant. CONCLUSIONS: ADC is a promising imaging biomarker that can help differentiate succinate dehydrogenase mutation-positive from mutation-negative paragangliomas in the head and neck.