Homeostatic control of redox status and health
Helmut Sies, Fulvio Ursini
Abstract
Research on oxidants and electrophiles has shifted from focusing on damage to biomolecules to the more fine-grained physiological arena. Redox transitions as excursions from a steady-state redox set point are continually ongoing in maintenance of redox balance. Current excitement on these topics results from the fact that recent research provided mechanistic insight, which gives rise to more concrete and differentiated questions. This Commentary focuses on redox eustress and the feedback restoration of steady state as concepts in active maintenance of physiological health, with brief discussion of redox stress response to viral infection, exemplified by COVID-19.
Topics & Concepts
RedoxSet pointCoronavirus disease 2019 (COVID-19)Oxidation reductionBiophysicsChemistryBiochemical engineeringNanotechnologyBiologyBiochemistryMedicineMaterials scienceControl engineeringEngineeringPathologyDiseaseOrganic chemistryInfectious disease (medical specialty)Genomics, phytochemicals, and oxidative stressFree Radicals and AntioxidantsRedox biology and oxidative stress