ZnO nanoparticle modified chitosan/borosilicate bioglass composite scaffold for inhibiting bacterial infection and promoting bone regeneration
Dewei Qiu, Ping Zhou, Jiawei Kang, Zhijun Chen, Zhiyong Xu, Hanwen Yang, Jun Tao, Fanrong Ai
Abstract
Abstract The treatment of implant-associated bone infection remains a significant clinical challenge. However, bone scaffolds with antimicrobial activity and osteoinductive properties can prevent these infections and improve clinical outcomes. In this study, borosilicate bioglass and chitosan composite scaffolds were prepared, and then the surface was modified with nano-zinc oxide. In vitro and in vivo experiments showed that the chitosan/borosilicate bioglass scaffolds have good degradation and osteogenic properties, while the oxidized Zinc scaffolds have better antibacterial properties.
Topics & Concepts
Borosilicate glassChitosanMaterials scienceComposite numberScaffoldRegeneration (biology)ZincIn vivoNanoparticleBiomedical engineeringChemical engineeringComposite materialNanotechnologyMedicineMetallurgyCell biologyEngineeringBiotechnologyBiologyBone Tissue Engineering MaterialsGraphene and Nanomaterials ApplicationsFacial Trauma and Fracture Management