Phylogenetics and biochemistry elucidate the evolutionary link between l-malate and l-lactate dehydrogenases and disclose an intermediate group of sequences with mix functional properties
Céline Brochier‐Armanet, Dominique Madern
Topics & Concepts
Malate dehydrogenaseBiologyBiochemistryEnzymeNAD+ kinaseLactate dehydrogenasePhylogenetic treeAmino acidPhylogeneticsAllosteric regulationIsozymeCitrate synthaseGeneEnzyme Structure and FunctionProtein Structure and DynamicsAmino Acid Enzymes and Metabolism