Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride
Liang Xian, Cui‐Ting Ma, Yinggen Ouyang, Jia‐Qi Di, Zhan‐Hui Zhang
Abstract
An eco‐friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one‐pot, three‐component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.
Topics & Concepts
ChemistryCatalysisFerricEnvironmentally friendlyPyrimidineChlorideOrganic chemistryCombinatorial chemistryCoupling reactionStereochemistryBiologyEcologyMulticomponent Synthesis of HeterocyclesQuinazolinone synthesis and applicationsClick Chemistry and Applications