Direct Synthesis of <i>ortho</i>-Halogenated Arylphosphonates via a Three-Component Reaction Involving Arynes
Yuanting Huang, Y. Hu, Yukun Han, Yingcong Ou, Yanping Huo, Xianwei Li, Qian Chen
Abstract
A three-component reaction involving arynes, trialkyl phosphites, and halides has been achieved under mild reaction conditions. This transformation provides a direct synthetic approach to ortho-halogenated arylphosphonates, which could be rapidly converted to diversely ortho-functionalized arylphosphorus compounds.
Topics & Concepts
AryneComponent (thermodynamics)ChemistryHalideReaction conditionsCombinatorial chemistryOrganic chemistryComputational chemistryMedicinal chemistryCatalysisPhysicsThermodynamicsCyclization and Aryne ChemistryCatalytic Alkyne ReactionsAsymmetric Synthesis and Catalysis