Organoids as host models for infection biology – a review of methods
Carmen Aguilar, Marta Alves da Silva, Margarida Saraiva, Mastura Neyazi, I. Anna S. Olsson, Sina Bartfeld
Abstract
Infectious diseases are a major threat worldwide. With the alarming rise of antimicrobial resistance and emergence of new potential pathogens, a better understanding of the infection process is urgently needed. Over the last century, the development of in vitro and in vivo models has led to remarkable contributions to the current knowledge in the field of infection biology. However, applying recent advances in organoid culture technology to research infectious diseases is now taking the field to a higher level of complexity. Here, we describe the current methods available for the study of infectious diseases using organoid cultures.
Topics & Concepts
OrganoidBiologyHost responseInfectious disease (medical specialty)Computational biologyImmunologyMedicineNeuroscienceDiseasePathologyImmune system3D Printing in Biomedical ResearchViral Infectious Diseases and Gene Expression in Insectsthermodynamics and calorimetric analyses