Hyperbaric Oxygen Treatment Improves Hearing Level <i>via</i> Attenuating TLR4/NF-κB Mediated Inflammation in Sudden Sensorineural Hearing Loss Patients.
Xue Hua Liu, Fang Liang, Xing Yuan Jia, Lin Zhao, Yan Zhou, Jing Yang
Abstract
OBJECTIVE: alteration of TLR4 and NF-κB expression. METHODS: = 60). Audiometric testing was performed pre- and post-treatment. TLR4, NF-кB, and TNF-α expression in peripheral blood of ISSHL patients and healthy control subjects was assessed by ELISA before and after treatment. RESULTS: < 0.01). CONCLUSION: HBOT alleviates hearing loss in ISSHL patients by suppressing the inflammatory response induced by TLR4 and NF-κB signaling.
Topics & Concepts
MedicineTLR4InflammationHyperbaric oxygenInternal medicineTumor necrosis factor alphaHearing lossGastroenterologyAnesthesiaAudiologyVestibular and auditory disordersInflammasome and immune disordersGlaucoma and retinal disorders