Treatment and follow‐up of children with chronic myeloid leukaemia in chronic phase (<scp>CML‐CP</scp>) in the tyrosine kinase inhibitor (<scp>TKI</scp>) era—Two decades of experience from the Tata Memorial Hospital paediatric <scp>CML</scp> (<scp>pCML</scp>) cohort
Nirmalya Roy Moulik, Swaminathan Keerthivasagam, Ankita Pandey, Jayesh Agiwale, Kriti Hegde, Gaurav Chatterjee, Chetan Dhamne, Maya Prasad, Akanksha Chichra, Shyam Srinivasan, Purvi Mohanty, H. K. Jain, Dhanlaxmi Shetty, Prashant Tembhare, Nikhil Patkar, Gaurav Narula, Papagudi Ganesan Subramanian, Shripad Banavali
Abstract
Tyrosine kinase inhibitors (TKIs) have drastically improved the outcomes of pCML (paediatric CML) but data on long-term off-target toxicities of TKIs in children are scarce. In this single-centre, retrospective cum prospective study of pCML in chronic phase, we report our experience of treating 173 children with imatinib and following them for long-term toxicities. Mean (SD) time to attain CHR, CCyR and MMR were 3.05 (2.1), 10.6 (8.4) and 43.4 (31.8) months respectively. DMR was not attained in 59 (34%) patients at last follow-up. Ten patients were switched to second-generation TKIs (2G-TKIs; nilotinib = 1/dasatinib = 9) due to poor/loss in response, of which seven had kinase domain mutations. Three patients progressed to the blastic phase. At a median follow-up of 84 (3-261) months, the 5-year EFS and OS for the entire cohort were 96.9% (95% CI: 93.4-100) and 98.7% (95% CI: 96.9-100) respectively. Screening for long-term toxicities revealed low bone density and hypovitaminosis D in 70% and 80% respectively. Other late effects included short stature (27%), delayed puberty (15%), poor sperm quality (43%) and miscellaneous endocrinopathies (8%). Children younger than 5 years at diagnosis were more susceptible to growth and endocrine toxicities (p = 0.009). Regular monitoring for long-term toxicities, timely intervention and trial of discontinuation whenever feasible are likely to improve the long-term outlook of pCML.