Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
Madeline E. Kavanagh, Benjamin D. Horning, Roli Khattri, Nilotpal Roy, Justine P. Lu, Landon R. Whitby, Elva Ye, Jaclyn C. Brannon, Albert E. Parker, Joel M. Chick, Christie L. Eissler, Ashley J. Wong, Joe L. Rodriguez, Socorro Rodiles, Kim Masuda, John R. Teijaro, Gabriel M. Simon, Matthew P. Patricelli, Benjamin F. Cravatt
Topics & Concepts
Allosteric regulationTyrosine kinase 2PhosphorylationBiochemistrySignal transductionChemistryJanus kinaseReceptor tyrosine kinaseKinaseCysteineCell biologyBiologyReceptorEnzymeGrowth factorPlatelet-derived growth factor receptorCytokine Signaling Pathways and InteractionsMyeloproliferative Neoplasms: Diagnosis and TreatmentCell Adhesion Molecules Research