Metal-free direct C–H phosphonation of N-heterocycles with diphenylphosphine oxides under mild conditions
Zhaonan Cai, Yaping Han, Yuecheng Zhang, Hong‐Yu Zhang, Jiquan Zhao, Shang‐Dong Yang
Abstract
Herein, metal-free phosphonation of N-heterocycles with diphenylphosphine oxides, promoted by 1,5-diazabicyclo[5,4,0]undec-5-ene utilizing air as a green oxidant in dimethyl carbonate as an eco-friendly solvent at room temperature, is presented.
Topics & Concepts
DiphenylphosphineChemistryMetalSolventDiphenylphosphine oxideInorganic chemistryPropylene carbonateEnvironmentally friendlyOrganic chemistryDimethyl carbonateMethanolCatalysisPhosphineElectrochemistryPhysical chemistryBiologyEcologyElectrodeSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry