Britannin as a novel NLRP3 inhibitor, suppresses inflammasome activation in macrophages and alleviates NLRP3-related diseases in mice
Jingjing Shao, Weifeng Li, Jinfeng Sun, Zaishou Zhuang, Julian Min, Xiaohong Long, Gaojun Wu, Haowen Xu, Guang Liang
Topics & Concepts
InflammasomePyroptosisPharmacologyInflammationSecretionKnockout mouseIC50MedicineChemistryCaspase 1Cancer researchImmunologyIn vitroReceptorBiochemistryInflammasome and immune disordersGout, Hyperuricemia, Uric Acid