Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis
Anna L. Smith, Julia C. Whitehall, Carla Bradshaw, David M. Gay, Fiona Robertson, Alasdair Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire Richardson, Bhavana Gupta, Iain McCallum, Stuart A.C. McDonald, Seamus B. Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Douglass M. Turnbull, Owen J. Sansom, Laura C. Greaves
Topics & Concepts
CarcinogenesisBiologyMitochondrial DNAOxidative phosphorylationCancer researchMutationMitochondrionColorectal cancerDNA damageSomatic cellCancerGeneticsGeneDNABiochemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismRNA modifications and cancer