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Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

Anna L. Smith, Julia C. Whitehall, Carla Bradshaw, David M. Gay, Fiona Robertson, Alasdair Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire Richardson, Bhavana Gupta, Iain McCallum, Stuart A.C. McDonald, Seamus B. Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Douglass M. Turnbull, Owen J. Sansom, Laura C. Greaves

2020Nature Cancer135 citationsDOIOpen Access PDF

Topics & Concepts

CarcinogenesisBiologyMitochondrial DNAOxidative phosphorylationCancer researchMutationMitochondrionColorectal cancerDNA damageSomatic cellCancerGeneticsGeneDNABiochemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismRNA modifications and cancer
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis | Litcius