Inositols administration: further insights on their biological role
D. Coldebella, G. Buzzaccarini, J. Ferrari, Z. Sleiman, M.N. D’Alterio, L. Della Corte, G. Cucinella, G. Gullo
Abstract
In the last decades, inositols attracted a growing interest since the acknowledgement of their role in insulin-activated signalling pathways. Myo-inositol (MI) and D-Chiro Inositol (DCI) are the most important isoforms and their use as insulin-sensitizer in treatment of polycystic ovarian syndrome is well known. New discoveries have paved the way for a wide range of new applications. For this reason, we collected the most interesting ideas and updates regarding inositols therapy to reason on innovative uses, with a particular focus in the field of infertility. We reviewed recent literature on inositol with a particular focus in the field of ovarian function and infertility. Recent researches on inositols are focusing on different signalling pathways other than the insulin-sensitizing one, such as inflammation signalling or androgens modulation. Furthermore, MI and DCI act in different ways and dosage and ratio seem to have different effects in different organs. Indeed, the use of inositols is developing promisingly in situations other than the treatment of insulin resistance and this is opening up new perspectives for increasingly personalized and effective therapies.