<i>Babesia microti</i> Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
Nolan Holbrook, Erik H. Klontz, Gordon Adams, Samuel R Schnittman, Nicolas C. Issa, Sheila A. Bond, John A. Branda, Jacob E. Lemieux
Abstract
Abstract We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis.
Topics & Concepts
AtovaquoneVirologyAzithromycinMedicineBabesiosisMutationBabesiaParasite hostingBiologyMicrobiologyGeneticsGeneImmunologyMalariaPlasmodium falciparumAntibioticsComputer scienceWorld Wide WebVector-borne infectious diseasesPneumocystis jirovecii pneumonia detection and treatmentParasitic Infections and Diagnostics