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Novel (thio)barbituric-phenoxy-N-phenylacetamide derivatives as potent urease inhibitors: synthesis, in vitro urease inhibition, and in silico evaluations

Saeb Sedaghati, Homa Azizian, Mohammad Nazari Montazer, Maryam Mohammadi‐Khanaposhtani, Mehdi Asadi, Fatemeh Moradkhani, Mehdi Shafiee Ardestani, Mohammad Asgari, Azadeh Yahya‐Meymandi, Mahmood Biglar, Bagher Larijani, Seyed Esmaeil Sadat-Ebrahimi, Alireza Foroumadi, Massoud Amanlou, Mohammad Mahdavi

2020Structural Chemistry27 citationsDOI

Topics & Concepts

ChemistryThioureaThio-UreaseIn silicoStereochemistryBarbituric acidIC50Docking (animal)In vitroActive siteCombinatorial chemistryEnzymeBiochemistryOrganic chemistryNursingMedicineGeneMicrobial Applications in Construction MaterialsBiochemical and Molecular ResearchEnzyme function and inhibition
Novel (thio)barbituric-phenoxy-N-phenylacetamide derivatives as potent urease inhibitors: synthesis, in vitro urease inhibition, and in silico evaluations | Litcius