Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition
Li Yan, Yixin Zhang, Da-Sheng Ning, Jing Chen, Shang‐Xuan Li, Zhi-Wei Mo, Yue-Ming Peng, Shi-Hui He, Ya-Ting Chen, Chunjuan Zheng, Jianjun Gao, Hao‐Xiang Yuan, Jing‐Song Ou, Zhi‐Jun Ou
Abstract
and NO, and expression of specific endothelial and mesenchymal markers. These data demonstrate that POVPC induces EndMT by increasing oxidative stress, which stimulates TGF-β/Smad signaling, leading to Snail-1 and Twist-1 activation. Simvastatin inhibited POVPC-induced EndMT by decreasing oxidative stress, suppressing TGF-β/Smad signaling, and inactivating Snail-1 and Twist-1. Our findings reveal a novel mechanism of atherosclerosis that can be inhibited by simvastatin.
Topics & Concepts
SimvastatinMesenchymal stem cellCell biologyChemistrySMADEndothelial stem cellTransforming growth factorBiologyBiochemistryEndocrinologyIn vitroCaveolin-1 and cellular processesCancer, Hypoxia, and MetabolismCardiac Fibrosis and Remodeling