Advances and challenges in understanding endosomal sorting and fission
Naava Naslavsky, Steve Caplan
Abstract
Endosomes play crucial roles in the cell, serving as focal and 'triage' points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Viewpoint aims to highlight recent advances in endosome research, including key endosomal functions such as sorting and fission. Moreover, the Viewpoint addresses key technical and conceptual challenges in studying endosomes.
Topics & Concepts
EndosomeSortingFissionCell biologyChemistryBiologyComputer scienceIntracellularPhysicsNeutronQuantum mechanicsProgramming languageCellular transport and secretionLipid Membrane Structure and BehaviorRetinal Development and Disorders