In-situ synthesis of reduced graphene oxide/silver nanoparticles (rGO/AgNPs) nanocomposites for high loading capacity of acetylsalicylic acid
Murni Handayani, Bagus Indra Suwaji, Geolita Ihsantia Ning Asih, Triana Kusumaningsih, Yuni Kusumastuti, Rochmadi, Isa Anshori
Abstract
Graphene has excellent properties which can be a promising material as nanocomposites for application in a drug delivery system (DDS). In this study, reduced graphene oxide/silver nanoparticles (rGO/AgNPs) nanocomposites was synthesized using a facile in-situ method for drug loading application of acetylsalicylic acid (ASA). The synthesis results were characterized by FESEM, EDX, UV-Vis, XRD, and Raman spectrophotometers analyses. The results showed that rGO/AgNPs nanocomposites was synthesized successfully. Drug loading application was performed using UV-Vis measurements. The loading results depicted that rGO/AgNPs is successfully created in high-capacity loading for ASA. Drug loading performances enhanced with the increasing loading time of ASA on rGO/AgNPs. The optimum percentage of drug loading capacity for ASA by rGO/AgNPs was ∼83% in a contact time of 30 hrs.