Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples
Anne K. Bozack, Elena Colicino, Allan C. Just, Robert O. Wright, Andrea Baccarelli, Rosalind J. Wright, Alison Lee
Abstract
). In replication analysis, 85% of DMRs overlapped with those identified in PRISM. Overall, DMRs and DMPs had higher methylation levels among females in cord blood and artery samples, but higher methylation levels among males in placenta samples. Further research is necessary to understand biological mechanisms that contribute to differences in sex-specific DNAm signatures across tissues, as well as to determine if sexual dimorphism in the epigenome impacts response to environmental stressors.
Topics & Concepts
dNaMBiologyDNA methylationCord bloodDifferentially methylated regionsPlacentaEpigeneticsMethylationReprogrammingSexual dimorphismAndrologyGeneticsPhysiologyFetusPregnancyEndocrinologyGeneGene expressionMedicineEpigenetics and DNA MethylationNeonatal Respiratory Health ResearchPrenatal Screening and Diagnostics