Aminopeptidase N-targeting nanomolecule-assisted delivery of VEGF siRNA to potentiate antitumour therapy by suppressing tumour revascularization and enhancing radiation response
Xue Li, Jiang Li, Chunyin Li, Qi Guo, Menglin Wu, Lin Su, Yan Dou, Xinhong Wu, Zhaoxun Xiao, Xuening Zhang
Abstract
Benefitting from superimposed effect of enhanced radiosensitizing and down-regulated angiogenic pathway, tGd–GNMs siRNA complex + X-ray treatment improves the tumouricidal effect and provide real-time imaging information to evaluate the antitumour effects.
Topics & Concepts
VEGF receptorsAminopeptidaseCancer researchRadiation therapyMedicineChemistryInternal medicineBiochemistryAmino acidLeucineNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer Research and Treatments