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Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA

Seham A. Ibrahim, Eman A. Fayed, Hala F. Rizk, Said E. Desouky, Ahmed Ragab

2021Bioorganic Chemistry70 citationsDOI

Topics & Concepts

AntimicrobialChemistryPyrazoleResazurinThiazoleBromideMinimum inhibitory concentrationMinimum bactericidal concentrationAntibioticsIC50Combinatorial chemistryStereochemistryIn vitroOrganic chemistryBiochemistrySynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Biological Evaluation
Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA | Litcius