Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?
Biplab K. Maiti
Abstract
), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.
Topics & Concepts
PapainProteaseViral replicationChemistryReplication (statistics)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)EnzymeBiochemistryBiologyCoronavirus disease 2019 (COVID-19)VirusMedicineDiseasePathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques